Toxicological studies of a metabolite of Streptomyces species on Brine shrimp and Mice
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Abstract
The cytotoxic activity of the crude chloroform extract of Streptomyces species and a pure compound, 4-hydroxy nitrobenzene (ZS-3) isolated from chloroform extract was determined by brine shrimp lethality bioassay. The LD50 values of chloroform extract and compound (ZS-3) and ampicillin trihydrate were found to be 5.6, 6.6 and 5.0 μgml-1, respectively. The acute toxicity of the compound (ZS-3) was also performed on Swiss albino mice. The median acute toxicity value (LD50) of ZS-3 was found to be 62 mg kg-1. Thus, the isolated compound ZS-3 seems to be safe for therapeutic use.
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Sathi ZS, Barman RK, Rahman M, Md Anwar Habib. Toxicological studies of a metabolite of Streptomyces species on Brine shrimp and Mice. TAJ. 2010;23(1):6-9. doi:10.70818/taj.2010.v023i01.003
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How to Cite
1.
Sathi ZS, Barman RK, Rahman M, Md Anwar Habib. Toxicological studies of a metabolite of Streptomyces species on Brine shrimp and Mice. TAJ. 2010;23(1):6-9. doi:10.70818/taj.2010.v023i01.003