p53 Expression and its Association with Histological Grade of Gastric Adenocarcinoma

Abstract

Background& Objective: Gastric cancer is known as one of the most common cancers and cause of death. Early and accurate diagnosis is an important tool for proper treatment response. Mutation of the p53 tumor suppressor gene is the most frequent genetic alteration observed in human cancers. The aim of this study was to evaluate the expression of p53 in gastric adenocarcinoma and its association with histological grade. Methods & Materials: This cross-sectional study was conducted in the Department of Pathology, Rajshahi Medical College, from September 2019 to August 2021. A total of 50 gastrectomy samples with a histologically confirmed diagnosis of gastric adenocarcinoma were included in this study. Expression of p53 was evaluated in formalin-fixed and paraffin embedded specimens by immunohistochemistry. Result: p53 expression was observed in all cases among which 31 (62%) patients showed low and 19 (38%) patients showed high p53 expression. Level of p53 expression was found significantly associated with histological grade. But, the p53 expression levels was not associated with the age of the patients with gastric adenocarcinoma (p>0.05). Conclusion: The expression of p53 involved in the progression and differentiation of gastric adenocarcinoma. These expression levels can be utilized as indicators of biological behavior and prognosis of gastric adenocarcinoma.