Association of Congenital CMV Infection in Pediatric Pulmonary Hypertension

Abstract

Background: Cytomegalovirus (CMV) is one of the leading causes of congenital infection in developed countries. Paediatric pulmonary hypertension is related with stunted growth, particularly in younger children. Pulmonary hypertension (PH) is a pathophysiologic condition that is typically related to pulmonary, cardiac, or other systemic illnesses. Pulmonary Hypertension can be the consequence of congenital CMV. Objective: To observed the congenital CMV association Infection in pulmonary hypertension in children. Materials and Methods: This observational study was included children included pulmonary hypertensive or non-hypertensive were admitted in the Department of Pediatric Cardiology in Bangladesh Shishu Hospital & Institute (BSHI), Dhaka, from 1st January to 31st November 2024. Total 90 patients aged between 1 month to 6 months with acynotic congenital heart disease, pulmonary hypertensive diagnosed by Doppler echocardiography where PAS >30 mm Hg (without any RVOT) or mean PAP >20 mm Hg were included. Among them 45 were pulmonary hypertension group and 45 were no pulmonary hypertension group.  Results: The mean hemoglobin 11.92(±1.85) vs 11.78(±1.63) (p>0.05), ESR   were 79.7 ± 35.7 vs 75.1 ± 26.5 (p>0.05), CRP 64.1 ± 54.4 vs 42.3 ± 31.3 (p<0.05), Leukocyte count (×103 cells/μL) 2395.7 (±1492.3) vs 8954.9 (±5867.5) (p<0.05) and platelet count were 89.18 ±47.16 vs 264.7 ±111.28 (p<0.05) were pulmonary hypertension and no pulmonary hypertension group respectively. Significant association was found CMV with Pulmonary hypertension (p <0.001). Conclusion: Positive correlation is found in pediatric pulmonary hyoertension patient with CMV infection.