Role of Magnesium Sulfate in Rheumatoid Arthritis patients

Abstract

Background: Rheumatoid Arthritis (RA) is a systemic inflammatory disease that causes joint destruction. It has long been recognized as a clinical illness associated with organ damage that is not limited to the musculoskeletal system. Malondialdehyde (MDA) is an oxidative stress biomarker. Conventional medications used to treat RA include methotrexate (MTX), sulfasalazine, hydroxychloroquine, and nonsteroidal anti-inflammatory drugs (NSAIDs). The aim of the study was to determine to oxidative stress and find out the role of magnesium in the management of RA. Materials and Methods: Cross-Sectional experimental type of study was carried out in the Department of Pharmacology and therapeutics, Rajshahi Medical College, Rajshahi from July 2021 to July 2022. Clinically diagnosed rheumatoid arthritis patients in the age group of 40-50 years and Rheumatoid arthritis patients treated with conventional medicine (Methotrexate, sulfasalazine, NSAIDs & Hydroxychloroquine) were included in this study. Total sample size was divided in to 2 groups: 15 patients treated with conventional medicine act as a control group and 15 patients treated with conventional medicine plus magnesium sulfate act as an experimental group. The study revealed that after 2 months of drug administration MDA level was more decreased in experimental group than the control group. Results:  Data were collected in 2 different age groups. The mean age of experimental group was 48.47± 12.09 years, and the control group was 45.13± 9.59 years. After 2 months drug administration, MDA level was more decreased in experimental group than the control group. So, Epsom salt may be used in RA patients. Conclusion: According to the study, the combination of Epsom salt and methotrexate was considerably more effective than methotrexate alone for RA patients.