Use of Danazol Alone with Danazol Combined with Evening Primrose Oil for the Treatment of Fibrocystic Breast Disease- A Comparative study of 200 cases

Background: Fibrocystic breast disease, also known as mammary dysplasia, is a non-cancerous condition that results in breast lumps, pain, and discomfort. Objective: This study aims to compare the effectiveness of Danazol alone versus Danazol combined with Evening Primrose Oil (EP) in treating fibrocystic breast disease. Method: A randomized controlled study was conducted on 200 outpatients at Chuadanga Sadar Hospital, Bangladesh, from January 2022 to December 2023. Patients were divided into two groups. Group A received Evening Primrose Oil 1000 mg twice daily combined with Danazol 100 mg twice daily for three months. Group B Danazol 100 mg twice daily alone for three months. Pain levels were compared using mean and standard deviation, and an independent sample T-test was employed. The efficacy of the treatments was further analyzed using the chi-square test. Results: The study included 200 patients with a mean age of 30.54 ± 4.53 years. The VAS pain score between the two groups showed a mean difference of 1.53±0.27. The results indicated significantly lower pain in the group using Danazol combined with EP capsules compared to Danazol alone (p = 0.001). The percentage of response in Group B was higher than in Group A. Conclusion: Danazol combined with Evening Primrose Oil is more effective in reducing pain in patients with fibrocystic breast disease compared to Danazol alone.