Clinical and Hematological Profiles of Dengue in Children

Background: Dengue Fever is a mosquito-borne viral disease that poses a significant health threat, particularly in pediatric populations in tropical and subtropical regions. Understanding the clinical presentations and hematological profiles of affected children is crucial for effective management and treatment strategies. Methods: A prospective observational study was conducted at a tertiary hospital from June 2022 to May 2023. Pediatric patients (aged ≤14 years) with laboratory-confirmed dengue infection via NS1 antigen or IgM antibody tests were included. Data collection involved clinical assessments, structured questionnaires, and laboratory investigations monitoring hematocrit, platelet counts, liver enzymes, ferritin, and D-Dimer levels. Results: Fever (85%), nausea (56.5%), and headache (36%) were the most common symptoms. Thrombocytopenia was observed, with a mean platelet count of 150.2 x10^3/μL. Mild liver involvement was indicated by elevated SGPT (45.0 U/L) and SGOT (48.0 U/L). Inflammatory markers like CRP (mean 10.0 mg/L) and D-Dimer were mildly elevated, suggesting an inflammatory response. Bleeding showed a negative correlation with platelet count (-0.35). Older children had lower platelet counts and higher serum creatinine, indicating age-related differences in disease severity. Conclusion: The study underscores the diverse clinical and hematological manifestations of Dengue Fever in children.